Archive | Science

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease:

Among patients with mild to moderate AD, 2000 IU/d of alpha tocopherol compared with placebo resulted in slower functional decline. There were no significant differences in the groups receiving memantine alone or memantine plus alpha tocopherol. These findings suggest benefit of alpha tocopherol in mild to moderate AD by slowing functional decline and decreasing caregiver […]

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Vitamin E

Anti-inflammatory Properties of Alpha and Gamma Tocopherol

Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, we discuss the anti-inflammatory properties of the two major forms of vitamin […]

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Flavanols Inversely Associated with Diabetes

Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The […]

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Which Form of Vitamin E, Alpha- or Gamma-Tocopherol, is Better?

Gamma-tocopherol concentrations in the blood have been reported to be significantly lower in coronary heart disease (CHD) patients compared to healthy subjects, suggesting that the low Gamma-tocopherol concentrations increased the risk of CHD. But Gamma-tocopherol may simply be an indicator that the patients did not eat a diet low in saturated fat and high in […]

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Vitamin E Supplements Decrease Gamma Tocopherol

It is well known that alpha-tocopherol supplements decrease plasma gamma-tocopherol concentrations. What is less well appreciated is that the body intentionally retains alpha-tocopherol. A special protein in the liver, the alpha-tocopherol transfer protein, preferentially maintains blood levels of alpha-tocopherol by incorporating only alpha-tocopherol into low-density lipoprotein (LDL) for tissue distribution. Our studies, currently in progress, […]

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